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For example, a medication might strongly activate brain GLP-1 receptors for appetite suppression while only partially activating gut receptors that contribute to nausea
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Given their effectiveness in controlling blood glucose and HbA1c levels, with additional weight loss benefits and minimal intrinsic risk of hypoglycemic episodes, GLP-1 RAs are now considered the first-line injectables for optimal glucose control in diabetic patients even before insulin treatment [18]
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